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Factors influence the freeze-dried vaccine immune response

① health of chickens: chickens only in the case of health. In order to produce a good immune response. If the feed quality is poor, vitamin deficiency, extensive management, before immunization with respiratory symptoms, E. coli and other diseases and the presence of immunosuppressive diseases. Can reduce the resistance of chickens. If the presence of respiratory symptoms in the body. After immunization not only can not produce a good immune response. There will be severe stress reactions (such as respiratory symptoms. Reaction time increased, the death rate increased Amoy), etc. So strengthen management. Prevention and treatment of other diseases do. Ensure healthy chickens before immunization vaccines can reduce the stress response. 

② maternal antibody levels: low or irregular when maternal antibody levels. Immune response in chickens on the performance of the more serious. Stress response can occur longer. The high level of maternal antibodies, neat coincide. Anti proper immune resistance. Immunological stress small. But the maternal antibodies are too high. Vaccines maternal antibodies can neutralize. Not produce enough protection rate. So make antibodies before immunization. To determine the best immunization days. 

③ immune pathways: the same vaccine, the immune pathways are different. Stress reactions vary in size. Such as Newcastle disease Ⅳ system when aerosol immunization, stress strongly, likely to cause mycoplasma and other diseases. Use eye, nasal stress is relatively small; while drinking immune stress response is very light. Newcastle I Department immunized better. Stress is small, while the water taken immunization. Intense stress response, chickens respiratory symptoms, the incidence of severe atypical Newcastle. When ILT eye. Often appear tearing, swollen eyes, coughing and other reactions. And take Tu anal way, this phenomenon rarely occurs. Should be based on different vaccines, virulence strength. Select the immune effects as well, small immune stress response pathways. 

④ SPF sources of non-live virus vaccines: Because the market most of the live virus vaccine derived from ordinary chick. Chickens inoculated this vaccine. Often occurs slowly call, salmonellosis, immunosuppressive and other diseases. Use SPF sources vaccine can reduce the extent of vaccine reactions. 

⑤ coop health conditions and duration of empty homes: coop sterilization is not complete. Empty homes not up to standard time requirements. Pathogenic microorganisms will be a substantial breeding. In the body, such as gastrointestinal, respiratory, reproductive track growth and reproduction. Latent infection. Once subjected to stress. Particularly immunoprecipitation lyophilized postemergence. Flocks severe vaccine reactions occurred. Cause respiratory inflammation, diarrhea, egg drop, dead Amoy increase and other diseases. 

⑥ virulence and immune vaccine doses: the virulence of the vaccine is too strong or residual virulence. Is also an important cause of vaccine reactions. Bronchitis H120 for the first free chicks. H52 for more than a month old chickens, but if chicks immunization. Vaccine reactions are relatively strong. Residual virulence ILT vaccine. Often there will be tears, swollen eyes, coughing and other reactions after immunization. The amount of over-vaccination. Can cause intense stress and immune suppression. In severe cases, can cause severe reactions approximate onset. So you want to be determined based vaccines and vaccination methods days chicken. And strictly control the immunization dose.


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