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Gentamicin Injection

 Our pharmaceutical exports in many countries such as Southeast Asia , Africa, and many neighboring and friendly countries. We not only provide Gentamycin injection. We also offer Active Pharmaceutical Ingredien (API) as well as technical support.

  I introduce my company to provide Gentamycin injection. he has good clinical trials.

  Drug Name

  Generic Name : gentamicin sulfate injection

  Product Name :

  Pinyin : Liusuan Qingdameisu Zhusheye

  This product is mainly composed of gentamicin sulfate , is a multi-component antibiotic -containing components C1, C1a, C2a, C2 and so on.

  Characters

  Colorless or almost colorless clear liquid.

  Toxicology editor

  This product aminoglycoside antibiotics. Have good antibacterial activity against a variety of Gram-negative bacteria and gram-positive bacteria , a variety of Enterobacteriaceae such as Escherichia coli , Klebsiella, Proteus, Salmonella , Shigella , Enterobacter , Serratia and Pseudomonas aeruginosa have a good antibacterial effect. Neisseria and Haemophilus influenzae moderately sensitive to the chemicals . For Brucella spp, Yersinia pestis , Acinetobacter spp , Campylobacter fetus also has a role. Staphylococcus ( including Staphylococcus aureus and coagulase-negative staphylococci ) and methicillin-sensitive strains of about 80% with good antibacterial effect, but methicillin-resistant strains of the most resistant to the chemicals . The role of Streptococcus pneumoniae and Streptococcus , Enterococcus is the most resistant to the chemicals . When this product is used in combination with the β -lactam , most available synergistic antibacterial effect.

  Mechanism of action of this product with bacterial 30S ribosomal subunit , inhibiting bacterial protein synthesis . In recent years, Gram-negative bacilli to gentamicin resistant strains have increased significantly.

  Pharmacokinetic

  This product is rapidly absorbed after intramuscular injection and completely in 0.5 to 1 hour to reach peak plasma concentration (Cmax). Blood elimination half-life (t1/2b) about 2 to 3 hours , renal dysfunction significantly extended. Low protein binding . In the body can be distributed in various tissues and body fluids, cells accumulate in the renal cortex , but also into the fetus through the placenta barrier easily through the blood - brain barrier into the brain tissue and cerebrospinal fluid . Not metabolized in the body by glomerular filtration of the prototype with the urine discharged within 24 hours after administration of 50% to 93 % of the administered amount .

  Hemodialysis and peritoneal dialysis dose can be cleared from the blood quite so significantly shorter half-life .


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